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Longevity and Aging

Dawn Bergeron • June 3, 2021

Nutrients for Longevity

The Top nutrients for longevity

Research has shown that certain nutrients found in whole foods support overall health and promote longer life expectancy. Examples of whole foods include fish, legumes, whole grains, berries, and veggies, particularly leafy greens. Keep reading to learn about the top ingredients and their benefits. content of your post goes here. 

Coenzyme Q10

  • Coenzyme Q10 (CoQ10) is a fat-soluble compound found in the heart, kidneys, liver, and pancreas of humans. 
  • Levels of CoQ10 are depleted by age-related oxidative stress, mitochondrial diseases, and statin use. Statins are lipid-lowering medications commonly prescribed for primary prevention of atherosclerotic cardiovascular disease (ASCVD) in aging adults.  
  • CoQ10 supplementation may improve blood sugar regulation
  • Has been shown to reduce glycosylated hemoglobin (HbA1C), which measures the average level of blood sugar over the last few months.
  • Deficiency in CoQ10 has been associated with type 2 diabetes, fibromyalgia, cancer, neurodegenerative, and heart disease.
  • CoQ10 is synthesized in the body and may be obtained from several food sources, including organ meats (e.g., liver, kidney, heart), sardines, herring, peanuts, spinach, and broccoli.

Omega-3 fatty acids

  • Omega-3 fatty acids are a group of long-chain fatty acids that include alpha-linoleic acid (ALA), eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA). While ALA may be obtained from plant foods, such as walnuts, flax, chia, and hemp seeds,  the conversion of ALA to EPA and DHA is limited in humans. 
  • EPA and DHA, considered to be the main health-promoting omega-3s, have been shown to increase levels of anti-inflammatory cytokines. 
  • High amounts of EPA and DHA fatty acids are found in fatty fish, such as salmon, sardines, herring, mackerel, anchovies, and cod liver oil.
  • A meta-analysis of 21 studies identified a link between regular fish consumption and reduced risk of certain chronic health conditions, such as breast cancer, (30) heart disease, (11) and osteoporosis. 

Probiotics and prebiotics

  • Another way to promote healthy aging is by supporting a balanced population of microbes that inhabit the gastrointestinal tract, known as the gut microbiota. 
  • Longevity studies in Italian and Chinese centenarians have identified the presence of some common beneficial bacteria in both cohorts, including Ruminococcaceae, Akkermansia, and Christensenellaceae families of bacteria. 
  • These bacteria are associated with immunomodulation, regulation of body mass index, and healthy homeostasis. Furthermore, greater diversity in microbiota is commonly considered an indicator of good health. 
  • Intestinal microbes feed on prebiotics, a type of carbohydrate found in foods such as leeks, garlic, onions, asparagus, Jerusalem artichokes, chicory, oats, wheat, chickpeas, and soybeans. 
  • A diet high in prebiotic fiber is associated with increased short-chain fatty acids produced by gut microbiota. This can protect against behavioral and inflammatory conditions. A Mediterranean diet is high in prebiotic fiber, as it includes plenty of vegetables, fruit, beans, and lentils.

B vitamins

  • Elevated homocysteine levels, a biomarker of aging in the body, are linked to reductions in grey matter in the brain, (6) as well as an increased risk of heart disease, Alzheimer’s disease, (12) bone loss, and bone fractures.
  • The body requires certain nutrients to metabolize homocysteine, including pyridoxine (vitamin B6), folate (vitamin B9), and cobalamin (vitamin B12). 
  • Good sources of B vitamins include liver, eggs, tuna, lamb, legumes, brown rice, dark leafy greens, nutritional yeast, milk, and yogurt.
  • The Heart Outcomes Prevention Evaluation (HOPE 2) study found that combined supplementation of vitamins B6, B12, and folate reduced homocysteine and risk of stroke by approximately 25%. 

Resveratrol

  • Resveratrol is a polyphenol primarily found in grape skins, red wine, grape juice, berries (e.g., blueberries, cranberries), and peanuts. Research has found resveratrol to exhibit antioxidant, anti-inflammatory, anti-aging, and anti-cancer effects.
  • Resveratrol supplementation has been shown to reduce biomarkers associated with inflammation, including reactive oxygen species (ROS), tumor necrosis factor alpha (TNFα) and interleukin-6 (IL-6). (25) In-vivo and in-vitro animal studies suggest that resveratrol may exert health benefits by inhibiting a process called glycation, which involves a reaction between proteins and sugars that produces advanced glycation end products (AGEs). 
  • AGEs are considered a biomarker of aging, as they can accumulate and cause damage to cells and tissues.

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